Trelle S, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011; 342:c7086
Non-steroidal anti-inflammatory drugs (NSAIDs) appear to be associated with increased cardiovascular risks.
Category: Clinical domain
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1173
Mar 04 2011
Antiherpetic antivirals in pregnancy and birth defects
Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 2010;304(8):859-866
No association was found between the use of aciclovir (Zovirax), or valaciclovir (Valtrex), in early pregnancy and major birth defects.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1046
Mar 02 2011
DHA on maternal depression and neurodevelopment
Makrides M, et al. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA. 2010; 304(15): 1675-1683
DHA supplements in the later half of pregnancy are not associated with improvements in maternal depression or infant neurodevelopment.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=989
Feb 28 2011
B-vitamins and omega-3 fatty acids on vascular disease
Galan P, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a RCT. BMJ 2010; 341:c6273
B-vitamin and low dose omega-3 fatty acid supplements are not associated with better vascular outcomes in people with ischaemic heart disease and stroke.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=993
Feb 25 2011
Incidence and progression of thyroid dysfunction in elderly
Gopinath B, et al. Five-year incidence and progression of thyroid dysfunction in an older population. Internal Medicine Journal 2010;40(9):642–649
The rate of progression from subclinical to overt hypothyroidism in older people is about 1 in 6 over five years.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=182
Feb 23 2011
Antipsychotics and the risk of venous thromboembolism
Parker C, Coupland C, Hippisley-Cox J. Antipsychotic drugs and risk of venous thromboembolism: nested case-control study. BMJ 2010;341:c4245.
Antipsychotic drugs are associated with a 32% increased risk of venous thromboembolism.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=191
Feb 21 2011
Maternal flu vaccination and flu infection in young infants
Eick AA, et al. Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med. 2010;0(2010):archpediatrics.2010.192
Maternal influenza vaccination during pregnancy has a limited effect on infant influenza-like illness.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=542
Feb 18 2011
Omega-3 fatty acids for prevention of atrial fibrillation
Kowey PR, et al. Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation. JAMA 2010; 304(21): 2363-72
High dose omega-3 fatty acids were not associated with a benefit in prevention of recurrent symptomatic AF.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1264
Feb 16 2011
Daily aspirin on long-term risk of death due to cancer
Rothwell PM, et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011; 377(9759): 31-41
Daily aspirin (≥ 75 mg) taken by participants in cardiovascular studies reduced the risk of cancer death.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=723
Feb 14 2011
Statins, coronary heart disease and abnormal LFTs
Athyros VG, et al. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with CHD and abnormal LFTs in GREACE Study: a post-hoc analysis. Lancet 2010; 376: 1916–22
Statin are effective and safe in patients with established coronary heart disease but with mild-to-moderate abnormal liver function tests.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=686
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