Tag: statins

Jun 25 2018

Do statins prevent dementia?

McGuinness et al. Cochrane database of systematic reviews 2016 Jan 4(1):CD003160
Statins should not be used as a prophylaxis against dementia, as the only indication. The limited evidence from high quality randomised trials suggests no effect.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1742

Aug 08 2016

Does co-enzyme Q10 reduce statin-related muscle pain?

Banach et al. Mayo Clin Proc 2015 Jan;90(1):24-34.
The effect of CoQ10 on muscle pain in people on statin therapy is uncertain with the evidence limited and inconsistent. CoQ10 cannot be recommended as a matter of routine supplementation to prevent muscle pain in people taking statins.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1696

Nov 08 2013

Are statins effective for primary prevention in people with low cardiovascular risk?

Tonelli M, et al. CMAJ 2011; 183(16): E1189-E1202
Statins appear to have a (small) cardiovascular benefit, even in individuals at low CVD risk.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1607

Apr 20 2011

Statins in primary prevention and all-cause mortality

Ray KK, et al. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 RCTs… Archives of Internal Medicine, 2010; 170(12): 1024-31 Statins were not associated with a benefit to all-cause mortality in a primary prevention setting.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1341

Feb 14 2011

Statins, coronary heart disease and abnormal LFTs

Athyros VG, et al. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with CHD and abnormal LFTs in GREACE Study: a post-hoc analysis. Lancet 2010; 376: 1916–22
Statin are effective and safe in patients with established coronary heart disease but with mild-to-moderate abnormal liver function tests.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=686