Category: Prevention

Jun 25 2018

Do statins prevent dementia?

McGuinness et al. Cochrane database of systematic reviews 2016 Jan 4(1):CD003160
Statins should not be used as a prophylaxis against dementia, as the only indication. The limited evidence from high quality randomised trials suggests no effect.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1742

Apr 30 2018

Does vitamin B3 (nicotinamide) prevent non-melanoma skin cancer?

Chen AC, et al. NEJM 2015 Oct 22;373(17):1618-26
Nicotinamide (vitamin B3) has a small-modest effect as prophylaxis against non-melanoma skin cancers

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1737

Aug 31 2017

Do vitamin D supplements reduce falls in older people living in the community?

Bolland et al. Lancet Diabetes Endocrinol 2014 Jul;2(7):573-80
The beneficial effect of vitamin D on falls in otherwise well community-dwelling people is likely to be small, if it exists at all. Its routine preventive use cannot be justified on the evidence.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1724

Aug 08 2016

Does co-enzyme Q10 reduce statin-related muscle pain?

Banach et al. Mayo Clin Proc 2015 Jan;90(1):24-34.
The effect of CoQ10 on muscle pain in people on statin therapy is uncertain with the evidence limited and inconsistent. CoQ10 cannot be recommended as a matter of routine supplementation to prevent muscle pain in people taking statins.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1696

Mar 15 2013

Do calcium supplements increase the risk of myocardial infarction?

Bolland M, et al. BMJ 2010; 341: c3691
Calcium supplements may increase the risk of myocardial infarction, but, there is substantial uncertainty in the estimate.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1592

Jun 22 2011

Dabigatran versus warfarin for atrial fibrillation

Connolly SJ, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361:1139-1151
Dabigatran (Pradaxa) is non-inferior to warfarin for the prevention of strokes or systemic embolism, in non-valvular atrial fibrillation.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1443

Apr 20 2011

Statins in primary prevention and all-cause mortality

Ray KK, et al. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 RCTs… Archives of Internal Medicine, 2010; 170(12): 1024-31 Statins were not associated with a benefit to all-cause mortality in a primary prevention setting.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1341

Mar 02 2011

DHA on maternal depression and neurodevelopment

Makrides M, et al. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA. 2010; 304(15): 1675-1683
DHA supplements in the later half of pregnancy are not associated with improvements in maternal depression or infant neurodevelopment.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=989

Feb 28 2011

B-vitamins and omega-3 fatty acids on vascular disease

Galan P, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a RCT. BMJ 2010; 341:c6273
B-vitamin and low dose omega-3 fatty acid supplements are not associated with better vascular outcomes in people with ischaemic heart disease and stroke.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=993

Feb 21 2011

Maternal flu vaccination and flu infection in young infants

Eick AA, et al. Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med. 2010;0(2010):archpediatrics.2010.192
Maternal influenza vaccination during pregnancy has a limited effect on infant influenza-like illness.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=542

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