Tag: NSAID

Is oral orphenadrine beneficial for acute low back pain?

Friedman et al. Ann Emerg Med 2018 Mar;71(3):348-56 e5
Orphenadrine provides no benefit when used in addition to naproxen for acute low back pain

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1747

Should PPIs be routinely co-prescribed with long-term NSAIDs?

Rostom et al. Cochrane database of systematic reviews 2002(4):CD002296.
Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs. Little data exists on clinical outcomes.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1719

NSAIDs as treatment for uncomplicated urinary tract infections

Gagyor et al. BMJ 2015 Dec 23;351:h6544.
NSAIDs should not be recommended as a first line treatment for uncomplicated UTIs in women. Compared to empirical antibiotics, women experienced a significantly greater burden of UTI symptoms.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1712

Cardiovascular safety of NSAIDs

Trelle S, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011; 342:c7086
Non-steroidal anti-inflammatory drugs (NSAIDs) appear to be associated with increased cardiovascular risks.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1173