Radonovich et al. JAMA 2019 Sep 3;322(9):824-33
The advantage of N95 respirators over surgical masks in controlled settings were not demonstrated in preventing staff influenza infection in routine primary care.
Steels E, et al. Inflammopharmacology 2019 Jun;27(3):475-85.
Palmitoylethanolamide (PEA) cannot be recommended as a routine therapy for knee osteoarthritis in Australian primary care,
Osani et al. Korean J Intern Med 2019 Mar 15
Duloxetine (60-120 mg daily) appears to have a small to moderate beneficial effect on knee osteoarthritis pain and function at 3 months, compared to placebo.
Beadle et al. Ann Emerg Med 2016 Jul;68(1):1-9 e1.
Nasal inhalation of isopropyl alcohol provides clinically important relief from acute nausea, of at least a short duration, in community ambulatory patients
Bisson et al. Cochrane database of systematic reviews 2013 Dec 13(12):CD003388
Eye movement desensitisation and reprocessing (EMDR) appears to be effective for post-traumatic stress disorder (PTSD) symptoms.
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Journal reference: Harrison D, Yamada J, Adams-Webber T, Ohlsson A, Beyene J, Stevens B. Sweet tasting solutions for reduction of needle-related procedural pain in children aged one to 16 years. Cochrane database of systematic reviews 2015 May 5(5):CD008408
Link: http://dx.doi.org/10.1002/14651858.CD008408.pub3
Published: May 2015
 Evidence cookie says… |
The effect of oral sweets on injection pain in children is unclear
- much of the data were from small studies with conflicting results
- there is better evidence for other approaches (e.g., distraction)
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The article was originally published in the February 2018 issue of Medical Observer, under the title “Licking needle pain”. (PDF)
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1733
Journal reference: Garbutt JC, Kampov-Polevoy AB, Gallop R, Kalka-Juhl L, Flannery BA. Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial. Alcohol Clin Exp Res 2010 Nov;34(11):1849-57
Link: http://dx.doi.org/10.1111/j.1530-0277.2010.01273.x
Published: November 2010
Evidence cookie says… |
Baclofen cannot be recommended as a routine treatment for alcohol use disorders
- the quality of the evidence is low overall
- some randomised trials demonstrate a beneficial effect, while others demonstrate no effect
- the larger trials have tended to demonstrate no effect
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1728
Journal reference: Bolland MJ, Grey A, Gamble GD, Reid IR. Vitamin D supplementation and falls: a trial sequential meta-analysis. Lancet Diabetes Endocrinol 2014 Jul;2(7):573-80
Link: http://dx.doi.org/10.1016/S2213-8587(14)70068-3
Published: July 2014
Evidence cookie says… |
The beneficial effect of vitamin D on falls in otherwise well community-dwelling people is likely to be small, if it exists at all.
- routine preventive use cannot be justified on the evidence.
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1724
Journal reference: Rostom A, Dube C, Wells G, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane database of systematic reviews 2002(4):CD002296.
Link: https://doi.org/10.1002/14651858.CD002296
Published: June 2011
Evidence cookie says… |
Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs
- little data exists on clinical outcomes
- prophylaxis should be considered for patients at increased risk of gastrointestinal toxicity
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1719
Journal reference: Gagyor I, Bleidorn J, Kochen MM, Schmiemann G, Wegscheider K, Hummers-Pradier E. Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial. Bmj 2015 Dec 23;351:h6544.
Link: http://doi.org/10.1136/bmj.h6544
Published: December 2015
Evidence cookie says… |
NSAIDs should not be recommended as a first line treatment for uncomplicated UTIs in women
- compared with women who received empirical antibiotics, those who received regular ibuprofen as treatment experienced more UTI symptoms
- however, most of the women who received NSAIDs did recovery from the UTI and used less antibiotics
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1712
Journal reference: Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R. Topical treatments for cutaneous warts. Cochrane database of systematic reviews 2012 Sep 12(9):CD001781
Link: http://dx.doi.org/10.1002/14651858.CD001781.pub3
Published: September 2012
Evidence cookie says… |
Duct tape should not be routinely recommended as wart therapy.
- There is no compelling evidence that duct tape is more effective than placebo.
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1707
Journal reference: Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane database Syst Rev 2007 Oct 17(4):CD003620
Link: https://dx.doi.org/10.1002/14651858.CD003620.pub3
Published: October 2007
Evidence cookie says… |
Milk thistle products cannot be recommended for chronic hepatitis B.
- There is limited/minimal research evidence available.
- What evidence exists is of unclear quality.
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1703
Journal reference: Cui JZ, Geng ZS, Zhang YH, Feng JY, Zhu P, Zhang XB. Effects of intracutaneous injections of sterile water in patients with acute low back pain: a randomized, controlled, clinical trial. Braz J Med Biol Res 2016 Mar;49(3)
Link: http://dx.doi.org/10.1590/1414-431X20155092
Published: March 2016
Evidence cookie says… |
Sterile water injections are of uncertain value in acute low back pain.
- Routine use of this intervention cannot be recommended based on a single study that has important threats to its internal validity.
- It may have a role in patients who consent after being informed to its uncertain value.
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1700
Journal reference: Banach M, Serban C, Sahebkar A, et al. Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. Mayo Clin Proc 2015 Jan;90(1):24-34.
Link: http://dx.doi.org/10.1016/j.mayocp.2014.08.021
Published: January 2015
Evidence cookie says… |
The effect of CoQ10 on muscle pain in people on statin therapy is uncertain.
- The research evidence is of limited quality and inconsistent.
- The range of best estimates includes no effect.
- CoQ10 cannot be recommended as a matter of routine supplementation to prevent muscle pain in people taking statins.
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1696
Journal reference: Zheng W, Li XB, Tang YL, Xiang YQ, Wang CY, de Leon J. Metformin for Weight Gain and Metabolic Abnormalities Associated With Antipsychotic Treatment: Meta-Analysis of Randomized Placebo-Controlled Trials. J Clin Psychopharmacol 2015 Oct;35(5):499-509.
Link: http://dx.doi.org/10.1097/JCP.0000000000000392
Published: October 2015
Evidence cookie says… |
The effect of metformin on cardiovascular disease in people living without diabetes on long-term antipsychotic medication is unknown.
- evidence exists on a number of surrogate endpoints that are CVD risks factors
- this evidence is heterogenous and its quality is not high
- metformin may have a small-to-moderate effect on weight gain
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Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1693
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