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Journal reference: Rondondi N, den Elzen WPJ, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-1374 [1]
Link: http://dx.doi.org/10.1001/jama.2010.1361
 Evidence cookie says... |
Subclinical hypothyroidism (elevated TSH with normal thyroxine levels) is associated with increased risk of coronary heart disease (CHD) events and mortality.
- TSH levels ≥ 7.0 mIU/L → trend for increasing risk.
- TSH level up to 6.9 mIU/L → no increased risk
It is reasonable that asymptomatic subclinical hypothyroidism with minimal increases of TSH up to 6.9 mIU/L not require treatment with thyroxine. However, testing for thyroid antibodies and TSH monitoring is recommended to detect conversion to overt hypothyroidism. |
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