Category: Clinical domain

Proton pump inhibitors with clopidogrel

van Boxel OS, et al. Cardiovascular and gastrointestinal outcomes in clopidogrel users on proton pump inhibitors: results of a large Dutch cohort study. Am J Gastroenterol 2010; 105: 2430–6
Concurrent proton pump inhibitors may increase the risk of cardiovascular outcomes in patients taking clopidogrel.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1322

Deaths after chiropractic upper cervical spine manipulation

Ernst E. Deaths after chiropractic: a review of published cases. Int J Clin Pract, July 2010; 64(8): 1162-5
Chiropractic, specifically, high-velocity, short-lever thrusts of the upper spine with rotation is associated with numerous deaths.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1312

Diagnostic x-ray and ultrasound and childhood cancer

Rajaraman P, et al. Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer… BMJ 2011; 342: d472
The excess risk of childhood cancer from diagnostic imaging in utero and early infancy remains unclear.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1295

Cannabis use and earlier onset of psychosis

Large M, et al. Cannabis use and earlier onset of psychosis. Arch Gen Psychiatry 2011: published online 7 February 2011
Cannabis may be causally related to psychotic illness but the evidence remains unclear.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1280

Osteoporosis in older men: the CHAMP study

Bleicher K, et al. Prevalence and treatment of osteoporosis in older Australian men: findings from the CHAMP study. MJA 2010;193:387-391
Osteoporosis is very common in men aged over 70 years and probably under-recognised and undertreated; 25% of participants had osteoporosis.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=228

Blood pressure measurement; conventional vs automated

Myers MG, et al. Conventional versus automated measurement of blood pressure in primary care patients with systolic hypertension: randomised parallel design controlled trial. BMJ 2011; 342: d286
Automated BP measurement is significantly closer to waking ambulatory BP than conventional manual measurement.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1229

HRT and breast cancer incidence and mortality

Chlebowski R, et al. Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA. 2010; 304 (15):1684-1692
Combined oestrogen and progestin HRT is associated with increased risk of invasive breast cancer, node-positivity, and all cause mortality.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1062

Conventional CPR vs chest compression only

Ogawa T, et al. Outcomes of chest compression only CPR versus conventional CPR conducted by lay people… BMJ 2011; 342: c7106
Conventional CPR may be associated with better rates of survival than chest compression only CPR when conducted by lay people in out of hospital arrests.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1116

Cranberry juice fails for urinary tract infections

Barbosa-Cesnik C, et al. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomised placebo-controlled trial. CID. 2011;52(1):23-30
Cranberry juice is not associated with a lower incidence of UTI recurrence than placebo juice in young, sexually active college women.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1096

Escitalopram for hot flushes in menopausal women

Freeman EW, et al. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA. 2001; 305(3): 267-74
Escitalopram is probably associated with a mild improvement in the frequency and severity of hot flushes in peri-menopausal women.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1075

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