Eyding D, et al. Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and SSRI. BMJ 2010;341:c4737
Reboxetine is no more effective than placebo for major depressive disorder.
Category: Clinical domain
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=250
Jan 17 2011
MLV-related virus in blood samples of patients with CFS
Lo S-C, et al. Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors. PNAS September 7, 2010 vol. 107 no. 36 15874-15879
There appears to be an association between chronic fatigue syndrome and murine leukaemia virus-related virus.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=241
Jan 14 2011
Placebos for irritable bowel syndrome
Kaptchuk TJ, et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS ONE 2010; 5(12): e15591
The positive results widely reported for placebo pills in consenting patients with irritable bowel syndrome are likely invalid due to serious methodological limitations in the study.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=749
Jan 12 2011
Severe hypoglycemia and risk of vascular events and death
Zoungas S, et al. Severe hypoglycemia and risk of vascular events and death. N Engl J Med 2010;363:1410-8
Severe hypoglycaemia is strongly associated with increased risk of vascular events and death (~ 350% ↑ risk).
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=206
Jan 10 2011
Tricyclic antidepressants and headaches
Jackson JL, et al. Tricyclic antidepressants and headaches: systematic review and meta-analysis. BMJ 2010;341:c5222
Tricyclic antidepressants are possibly/probably effective in reducing the frequency and intensity of migraine and tension-type headaches.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=743
Jan 07 2011
Travel to Indian subcontinent and resistant E. coli UTIs
Freeman JT, et al. Community-onset genitourinary tract infection due to CTX-M-15-producing E. coli among travelers to the Indian subcontinent in NZ. CID 2008; 47:689–92
Travel to the Indian subcontinent is associated with multi-resistant E. coli causing UTIs in the community.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=277
Jan 05 2011
Subclinical hypothyroidism and coronary heart disease
Rondondi N, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-1374.
Subclinical hypothyroidism (elevated TSH with normal thyroxine levels) is associated with increased risk of coronary heart disease (CHD) events and mortality.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=162
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