Category: Randomised controlled trial

Nov 06 2017

Baclofen as treatment for alcohol use disorders

Garbutt et al. Alcohol Clin Exp Res 2010 Nov;34(11):1849-57
Baclofen cannot be recommended as a routine treatment for alcohol use disorders. The quality of the evidence is low overall.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1728

Aug 31 2017

Do vitamin D supplements reduce falls in older people living in the community?

Bolland et al. Lancet Diabetes Endocrinol 2014 Jul;2(7):573-80
The beneficial effect of vitamin D on falls in otherwise well community-dwelling people is likely to be small, if it exists at all. Its routine preventive use cannot be justified on the evidence.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1724

Jul 03 2017

Should PPIs be routinely co-prescribed with long-term NSAIDs?

Rostom et al. Cochrane database of systematic reviews 2002(4):CD002296.
Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs. Little data exists on clinical outcomes.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1719

Jun 09 2017

NSAIDs as treatment for uncomplicated urinary tract infections

Gagyor et al. BMJ 2015 Dec 23;351:h6544.
NSAIDs should not be recommended as a first line treatment for uncomplicated UTIs in women. Compared to empirical antibiotics, women experienced a significantly greater burden of UTI symptoms.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1712

Mar 01 2017

Duct tape to treat cutaneous warts

Kwok CS, et al. Cochrane database of systematic reviews 2012 Sep 12(9):CD001781
Duct tape should not be routinely recommended as wart therapy. There is no compelling evidence that duct tape is more effective than placebo.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1707

Dec 05 2016

Milk thistle for chronic hepatitis B

Rambaldi et al. Cochrane database Syst Rev 2007 Oct 17(4):CD003620
Milk thistle products cannot be recommended for chronic hepatitis B. Only limited research evidence of unclear/poor quality exists.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1703

Oct 10 2016

Sterile water injections for acute low back pain

Cui JZ, et al. Braz J Med Biol Res 2016 Mar;49(3)
Sterile water injections are of uncertain value in acute low back pain. It may have a role in patients who consent after being informed to its uncertain value.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1700

Aug 08 2016

Does co-enzyme Q10 reduce statin-related muscle pain?

Banach et al. Mayo Clin Proc 2015 Jan;90(1):24-34.
The effect of CoQ10 on muscle pain in people on statin therapy is uncertain with the evidence limited and inconsistent. CoQ10 cannot be recommended as a matter of routine supplementation to prevent muscle pain in people taking statins.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1696

Jun 14 2016

Metformin as prevention in people taking antipsychotic medication

Zheng et al. J Clin Psychopharmacol 2015 Oct;35(5):499-509.
The effect of metformin on cardiovascular disease in people living without diabetes on long-term antipsychotic medication is unknown.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1693

Feb 19 2016

Aspirin as DVT prophylaxis for high risk long-haul travellers

Cesarone MR, et al. Angiology 2002 Jan-Feb;53(1):1-6.
It is unclear whether aspirin is effective as DVT prophylaxis for high risk long-haul travellers. The lack of evidence should preclude it from being recommended.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1687

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