Category: Clinical domain

Symptoms and signs of croup and epiglottitis

Tibballs J, Watson T. Symptoms and signs differentiating croup and epiglottitis. Journal of Paediatrics and Child Health. (2010) 10.1111/j.1440-1754.2010.01892.x
Cough and drooling can be helpful in differentiating croup and epiglottitis in children with acute stridor.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=562

Antihypertensive drugs and the risk of cancer

Bangalore S, et al. Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials. Lancet Oncol (2010)
Antihypertensive drugs do not appear to increase cancer risk or cancer-related deaths.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=549

Antibiotics for acute otitis media in young children

Tähtinen PA, et al. A placebo-controlled trial of antimicrobial treatment for acute otitis media. N Engl J Med 2011; 364: 116-26
Children aged 6-35 months with acute otitis media may benefit from amoxicillin-clavulanate but at the cost of adverse events.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1065

Predicting the need for imaging in febrile urinary tract infections

van Nieuwkoop C, et al. Predicting the need for radiologic imaging in adults with febrile urinary tract infection. CID 2010;51(11):1266–1272
A simple clinical prediction rule may predict patients with febrile urinary tract infection who would not benefit from radiologic imaging.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=363

PSA at age 60 and death or metastasis from prostate cancer

Vickers AJ, et al. PSA concentration at age 60 and death or metastasis from prostate cancer: case-control study. BMJ 2010;341:c4521
Men aged 60 years with a PSA < 1.0 ng/mL have less than a 0.5% risk of prostate cancer metastasis or prostate cancer death by age 85.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=289

Effect of home testing of INR on clinical events

Matchar DB, et al. Effect of home testing of INR on clinical events. N Engl J Med 2010;363:1608-20
Home INR self-testing does not appear to improve or worsen strokes, major bleeds or death when compared to high quality practice based management of anticoagulation.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=282

Cryotherapy vs topical salicylic acid for cutaneous warts

Bruggink SC, et al. Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: a randomized controlled trial. CMAJ. October 19, 2010; 182 (15)
Cryotherapy with liquid nitrogen is more effective than topical salicylic acid ointment for treatment of cutaneous common warts.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=807

Glucosamine and/or chondroitin for osteoarthritis

Wandel S, et al. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ 2010;341:c4675
Glucosamine, chondroitin and their combination do not improve pain or reduce joint space loss in osteoarthritis of the hip or knee.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=270

Drug company information and physicians’ prescribing

Spurling GK, et al. Information from pharmaceutical companies and the quality, quantity and cost of physicians’ prescribing: a systematic review. PLoS Med, 2010; 7(10)
Exposure does not improve prescribing quality, reduce prescribing frequency or reduce prescribing costs.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=265

Chronic kidney disease and risk of cardiovascular disease

Di Angelantonio E, et al. CKD and risk of major CVD and no-vascular mortality: prospective population based cohort study. BMJ. 2010;341:c4986
Even the earliest stages of CKD seem to be independently associated with an increased risk of subsequent CHD.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=262

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