Category: Randomised controlled trial

Aug 19

Can cranberry prevent UTIs?

Barbosa-Cesnik C, et al. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomised placebo-controlled trial. Clinical Infectious Diseases 2011; 52(1): 23-30
Cranberry juice is unlikely to be an effective prophylactic for recurrent urinary tract infections in young women.

Jun 22

Dabigatran versus warfarin for atrial fibrillation

Connolly SJ, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361:1139-1151
Dabigatran (Pradaxa) is non-inferior to warfarin for the prevention of strokes or systemic embolism, in non-valvular atrial fibrillation.

May 04

Inhaled corticosteroids as rescue treatment

Martinez FD, et al. Use of beclomethasone dipropionate as rescue treatment for mild persistent asthma…. Lancet 2011; 377: 650–57
Inhaled beclomethasone (Qvar) used as rescue therapy with salbutamol is likely better than salbutamol alone, for children with mild persistent asthma who do not take regular inhaled corticosteroids.

Mar 18

Blood pressure measurement; conventional vs automated

Myers MG, et al. Conventional versus automated measurement of blood pressure in primary care patients with systolic hypertension: randomised parallel design controlled trial. BMJ 2011; 342: d286
Automated BP measurement is significantly closer to waking ambulatory BP than conventional manual measurement.

Mar 16

HRT and breast cancer incidence and mortality

Chlebowski R, et al. Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA. 2010; 304 (15):1684-1692
Combined oestrogen and progestin HRT is associated with increased risk of invasive breast cancer, node-positivity, and all cause mortality.

Mar 11

Cranberry juice fails for urinary tract infections

Barbosa-Cesnik C, et al. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomised placebo-controlled trial. CID. 2011;52(1):23-30
Cranberry juice is not associated with a lower incidence of UTI recurrence than placebo juice in young, sexually active college women.

Mar 09

Escitalopram for hot flushes in menopausal women

Freeman EW, et al. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA. 2001; 305(3): 267-74
Escitalopram is probably associated with a mild improvement in the frequency and severity of hot flushes in peri-menopausal women.

Mar 02

DHA on maternal depression and neurodevelopment

Makrides M, et al. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA. 2010; 304(15): 1675-1683
DHA supplements in the later half of pregnancy are not associated with improvements in maternal depression or infant neurodevelopment.

Feb 28

B-vitamins and omega-3 fatty acids on vascular disease

Galan P, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a RCT. BMJ 2010; 341:c6273
B-vitamin and low dose omega-3 fatty acid supplements are not associated with better vascular outcomes in people with ischaemic heart disease and stroke.

Feb 18

Omega-3 fatty acids for prevention of atrial fibrillation

Kowey PR, et al. Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation. JAMA 2010; 304(21): 2363-72
High dose omega-3 fatty acids were not associated with a benefit in prevention of recurrent symptomatic AF.