Category: Cohort study

Apr 13

Proton pump inhibitors with clopidogrel

van Boxel OS, et al. Cardiovascular and gastrointestinal outcomes in clopidogrel users on proton pump inhibitors: results of a large Dutch cohort study. Am J Gastroenterol 2010; 105: 2430–6
Concurrent proton pump inhibitors may increase the risk of cardiovascular outcomes in patients taking clopidogrel.

Mar 04

Antiherpetic antivirals in pregnancy and birth defects

Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 2010;304(8):859-866
No association was found between the use of aciclovir (Zovirax), or valaciclovir (Valtrex), in early pregnancy and major birth defects.

Feb 25

Incidence and progression of thyroid dysfunction in elderly

Gopinath B, et al. Five-year incidence and progression of thyroid dysfunction in an older population. Internal Medicine Journal 2010;40(9):642–649
The rate of progression from subclinical to overt hypothyroidism in older people is about 1 in 6 over five years.

Feb 21

Maternal flu vaccination and flu infection in young infants

Eick AA, et al. Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med. 2010;0(2010):archpediatrics.2010.192
Maternal influenza vaccination during pregnancy has a limited effect on infant influenza-like illness.

Feb 07

Predicting the need for imaging in febrile urinary tract infections

van Nieuwkoop C, et al. Predicting the need for radiologic imaging in adults with febrile urinary tract infection. CID 2010;51(11):1266–1272
A simple clinical prediction rule may predict patients with febrile urinary tract infection who would not benefit from radiologic imaging.

Jan 21

Chronic kidney disease and risk of cardiovascular disease

Di Angelantonio E, et al. CKD and risk of major CVD and no-vascular mortality: prospective population based cohort study. BMJ. 2010;341:c4986
Even the earliest stages of CKD seem to be independently associated with an increased risk of subsequent CHD.