Nov 07

St John’s wort for minor depression

Rapaport MH, et al. Journal of Psychiatric Research 2011; 45(7): 931-941
St John’s wort is probably ineffective for minor depression.

Mar 09

Escitalopram for hot flushes in menopausal women

Freeman EW, et al. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA. 2001; 305(3): 267-74
Escitalopram is probably associated with a mild improvement in the frequency and severity of hot flushes in peri-menopausal women.

Jan 19

Reboxetine for acute treatment of major depression

Eyding D, et al. Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and SSRI. BMJ 2010;341:c4737
Reboxetine is no more effective than placebo for major depressive disorder.

Jan 10

Tricyclic antidepressants and headaches

Jackson JL, et al. Tricyclic antidepressants and headaches: systematic review and meta-analysis. BMJ 2010;341:c5222
Tricyclic antidepressants are possibly/probably effective in reducing the frequency and intensity of migraine and tension-type headaches.