Tag: PPI

Jul 03

Should PPIs be routinely co-prescribed with long-term NSAIDs?

Rostom et al. Cochrane database of systematic reviews 2002(4):CD002296.
Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs. Little data exists on clinical outcomes.

Apr 13

Proton pump inhibitors with clopidogrel

van Boxel OS, et al. Cardiovascular and gastrointestinal outcomes in clopidogrel users on proton pump inhibitors: results of a large Dutch cohort study. Am J Gastroenterol 2010; 105: 2430–6
Concurrent proton pump inhibitors may increase the risk of cardiovascular outcomes in patients taking clopidogrel.