Spurling GK, et al. Information from pharmaceutical companies and the quality, quantity and cost of physicians’ prescribing: a systematic review. PLoS Med, 2010; 7(10)
Exposure does not improve prescribing quality, reduce prescribing frequency or reduce prescribing costs.
Kaptchuk TJ, et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS ONE 2010; 5(12): e15591
The positive results widely reported for placebo pills in consenting patients with irritable bowel syndrome are likely invalid due to serious methodological limitations in the study.