Paracetamol for acute low-back pain

Williams et al. Lancet 2014;384(9954):1586-96.
Paracetamol does not have an effect on time to recovery for acute low-back pain in the general practice setting.


Antibiotic drops for conjunctivitis in children

Rose PW, Harnden A, Brueggemann AB, et al. Lancet 2005; 366(9479): 37-43
The majority of children are cured by day 7 regardless of treatment.


Inhaled corticosteroids as rescue treatment

Martinez FD, et al. Use of beclomethasone dipropionate as rescue treatment for mild persistent asthma…. Lancet 2011; 377: 650–57
Inhaled beclomethasone (Qvar) used as rescue therapy with salbutamol is likely better than salbutamol alone, for children with mild persistent asthma who do not take regular inhaled corticosteroids.


Daily aspirin on long-term risk of death due to cancer

Rothwell PM, et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011; 377(9759): 31-41
Daily aspirin (≥ 75 mg) taken by participants in cardiovascular studies reduced the risk of cancer death.


Statins, coronary heart disease and abnormal LFTs

Athyros VG, et al. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with CHD and abnormal LFTs in GREACE Study: a post-hoc analysis. Lancet 2010; 376: 1916–22
Statin are effective and safe in patients with established coronary heart disease but with mild-to-moderate abnormal liver function tests.


Antihypertensive drugs and the risk of cancer

Bangalore S, et al. Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials. Lancet Oncol (2010)
Antihypertensive drugs do not appear to increase cancer risk or cancer-related deaths.