Connolly SJ, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361:1139-1151
Dabigatran (Pradaxa) is non-inferior to warfarin for the prevention of strokes or systemic embolism, in non-valvular atrial fibrillation.
Jun
22
Dabigatran versus warfarin for atrial fibrillation
by Michael Tam
Apr
13
Proton pump inhibitors with clopidogrel
van Boxel OS, et al. Cardiovascular and gastrointestinal outcomes in clopidogrel users on proton pump inhibitors: results of a large Dutch cohort study. Am J Gastroenterol 2010; 105: 2430–6
Concurrent proton pump inhibitors may increase the risk of cardiovascular outcomes in patients taking clopidogrel.
Apr
06
Deaths after chiropractic upper cervical spine manipulation
by Michael Tam
Ernst E. Deaths after chiropractic: a review of published cases. Int J Clin Pract, July 2010; 64(8): 1162-5
Chiropractic, specifically, high-velocity, short-lever thrusts of the upper spine with rotation is associated with numerous deaths.
Feb
28
B-vitamins and omega-3 fatty acids on vascular disease
by Michael Tam
Galan P, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a RCT. BMJ 2010; 341:c6273
B-vitamin and low dose omega-3 fatty acid supplements are not associated with better vascular outcomes in people with ischaemic heart disease and stroke.
Feb
02
Effect of home testing of INR on clinical events
by Michael Tam
Matchar DB, et al. Effect of home testing of INR on clinical events. N Engl J Med 2010;363:1608-20
Home INR self-testing does not appear to improve or worsen strokes, major bleeds or death when compared to high quality practice based management of anticoagulation.