Jan 05

Subclinical hypothyroidism and coronary heart disease

Journal reference: Rondondi N, den Elzen WPJ, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-1374 [1]

Link: http://dx.doi.org/10.1001/jama.2010.1361

Evidence cookie says...

Subclinical hypothyroidism (elevated TSH with normal thyroxine levels) is associated with increased risk of coronary heart disease (CHD) events and mortality.

  • TSH levels ≥ 7.0 mIU/L → trend for increasing risk.
  • TSH level up to 6.9 mIU/L → no increased risk

It is reasonable that asymptomatic subclinical hypothyroidism with minimal increases of TSH up to 6.9 mIU/L not require treatment with thyroxine. However, testing for thyroid antibodies and TSH monitoring is recommended to detect conversion to overt hypothyroidism.

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Dec 30

Morsels of Evidence begins!

The Evidence Cookie

Morsels of Evidence is a new website dedicated to providing brief, digestible and clinically relevant articles on contemporaneous published evidence from medical journals to Australian general practitioners working in primary health care.  It is hoped that this will help assist GPs to practice evidence based medicine by translating findings in medical research to clinical practice suggestions.

Each article is prefaced with an “evidence cookie”; an evidence based summary that can be absorbed in a glance.  A more detailed summary follows for those whose appetite for knowledge has been whetted.

The first evidence based morsel will be published next week on 5th January 2011, and further articles will be published on Mondays, Wednesdays, and Fridays.

To get the best use from Morsels of Evidence, please contribute by sharing your knowledge in the comments section of the articles and subscribe to the mailing list to get new articles from Morsels of Evidence sent directly to your e-mail.