Tag: BMJ

Feb 23

Antipsychotics and the risk of venous thromboembolism

Parker C, Coupland C, Hippisley-Cox J. Antipsychotic drugs and risk of venous thromboembolism: nested case-control study. BMJ 2010;341:c4245.
Antipsychotic drugs are associated with a 32% increased risk of venous thromboembolism.

Feb 04

PSA at age 60 and death or metastasis from prostate cancer

Vickers AJ, et al. PSA concentration at age 60 and death or metastasis from prostate cancer: case-control study. BMJ 2010;341:c4521
Men aged 60 years with a PSA < 1.0 ng/mL have less than a 0.5% risk of prostate cancer metastasis or prostate cancer death by age 85.

Jan 28

Glucosamine and/or chondroitin for osteoarthritis

Wandel S, et al. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ 2010;341:c4675
Glucosamine, chondroitin and their combination do not improve pain or reduce joint space loss in osteoarthritis of the hip or knee.

Jan 21

Chronic kidney disease and risk of cardiovascular disease

Di Angelantonio E, et al. CKD and risk of major CVD and no-vascular mortality: prospective population based cohort study. BMJ. 2010;341:c4986
Even the earliest stages of CKD seem to be independently associated with an increased risk of subsequent CHD.

Jan 19

Reboxetine for acute treatment of major depression

Eyding D, et al. Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and SSRI. BMJ 2010;341:c4737
Reboxetine is no more effective than placebo for major depressive disorder.

Jan 10

Tricyclic antidepressants and headaches

Jackson JL, et al. Tricyclic antidepressants and headaches: systematic review and meta-analysis. BMJ 2010;341:c5222
Tricyclic antidepressants are possibly/probably effective in reducing the frequency and intensity of migraine and tension-type headaches.