Category: Meta-analysis

Mar 07 2011

Cardiovascular safety of NSAIDs

Trelle S, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011; 342:c7086
Non-steroidal anti-inflammatory drugs (NSAIDs) appear to be associated with increased cardiovascular risks.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1173

Feb 16 2011

Daily aspirin on long-term risk of death due to cancer

Rothwell PM, et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011; 377(9759): 31-41
Daily aspirin (≥ 75 mg) taken by participants in cardiovascular studies reduced the risk of cancer death.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=723

Feb 09 2011

Antihypertensive drugs and the risk of cancer

Bangalore S, et al. Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials. Lancet Oncol (2010)
Antihypertensive drugs do not appear to increase cancer risk or cancer-related deaths.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=549

Jan 28 2011

Glucosamine and/or chondroitin for osteoarthritis

Wandel S, et al. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ 2010;341:c4675
Glucosamine, chondroitin and their combination do not improve pain or reduce joint space loss in osteoarthritis of the hip or knee.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=270

Jan 24 2011

Drug company information and physicians’ prescribing

Spurling GK, et al. Information from pharmaceutical companies and the quality, quantity and cost of physicians’ prescribing: a systematic review. PLoS Med, 2010; 7(10)
Exposure does not improve prescribing quality, reduce prescribing frequency or reduce prescribing costs.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=265

Jan 19 2011

Reboxetine for acute treatment of major depression

Eyding D, et al. Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and SSRI. BMJ 2010;341:c4737
Reboxetine is no more effective than placebo for major depressive disorder.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=250

Jan 10 2011

Tricyclic antidepressants and headaches

Jackson JL, et al. Tricyclic antidepressants and headaches: systematic review and meta-analysis. BMJ 2010;341:c5222
Tricyclic antidepressants are possibly/probably effective in reducing the frequency and intensity of migraine and tension-type headaches.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=743

Jan 05 2011

Subclinical hypothyroidism and coronary heart disease

Rondondi N, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-1374.
Subclinical hypothyroidism (elevated TSH with normal thyroxine levels) is associated with increased risk of coronary heart disease (CHD) events and mortality.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=162

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