Category: Randomised controlled trial

Oct 30

Starting allopurinol in acute gout

Hill et al. J Clin Rheumatol 2015;21(3):120-5.
It is unclear what effect starting allopurinol in acute has on symptoms, due to the lack of good evidence. It may be preferable to avoid starting allopurinol in an acute attack, but this should not be a dogmatic stance.

Sep 04

Corticosteroid injections for tennis elbow

Olaussen et al. BMJ Open 2013;3(10):e003564
Corticosteroid injections should generally be avoided for tennis elbow (lateral epicondylitis).

May 15

Paracetamol for acute low-back pain

Williams et al. Lancet 2014;384(9954):1586-96.
Paracetamol does not have an effect on time to recovery for acute low-back pain in the general practice setting.

Mar 13

Yoghurt to prevent antibiotic-associated diarrhoea in children

Fox MJ, et al. BMJ Open 2015;5(1): e006474
Probiotic yoghurt appears to reduce the incidence of diarrhoea in children receiving antibiotics in general practice settings.

Nov 07

St John’s wort for minor depression

Rapaport MH, et al. Journal of Psychiatric Research 2011; 45(7): 931-941
St John’s wort is probably ineffective for minor depression.

Jul 11

Echinacea and the common cold in children

Taylor JA, et al. JAMA 2003; 290(21): 2824-30
Echinacea does not appear to be an effective treatment for the common cold in children.

May 24

Is yoghurt helpful for antibiotic-associated diarrhoea?

Conway S, Hart A, Clark A, Harvey I. BJGP 2007; 57(545): 953-959
Yoghurt eaters in this study might have suffered less antibiotic-associated diarrhoea as compared to those who ate no yoghurt.

Sep 28

Can exercise be a treatment for depression?

Chalder M, et al. BMJ 2012; 344:e2758
Recommending structured moderate or vigorous exercise in addition to routine GP care is not effective for the treatment of depression.

Jun 08

Antibiotic drops for conjunctivitis in children

Rose PW, Harnden A, Brueggemann AB, et al. Lancet 2005; 366(9479): 37-43
The majority of children are cured by day 7 regardless of treatment.

Oct 24

Is cryotherapy the best treatment for common warts?

Bruggink SC, et al. CMAJ 2010; 182(15): 1624-30
LN2 cryotherapy is likely more effective than topical salicyclic acid for the treatment of common warts in primary care.