Category: Endocrinology

Do vitamin D supplements reduce falls in older people living in the community?

Bolland et al. Lancet Diabetes Endocrinol 2014 Jul;2(7):573-80
The beneficial effect of vitamin D on falls in otherwise well community-dwelling people is likely to be small, if it exists at all. Its routine preventive use cannot be justified on the evidence.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1724

Metformin as prevention in people taking antipsychotic medication

Zheng et al. J Clin Psychopharmacol 2015 Oct;35(5):499-509.
The effect of metformin on cardiovascular disease in people living without diabetes on long-term antipsychotic medication is unknown.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1693

Mediterranean diets in type 2 diabetes

Ajala O, et al. Am J Clin Nutr 2013; 97(3): 505-516
The Mediterranean diet appears to be as good as other diets at improving glycaemic control in patients with type 2 diabetes.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1610

Type 2 diabetes and increased risk for malaria

Danquah I, et al. Type 2 diabetes mellitus and increased risk for malaria infection. Emerg Inf Dis 2010; 16 (1): 1601-1604
There may be an association between type 2 diabetes and malaria infection.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1433

Osteoporosis in older men: the CHAMP study

Bleicher K, et al. Prevalence and treatment of osteoporosis in older Australian men: findings from the CHAMP study. MJA 2010;193:387-391
Osteoporosis is very common in men aged over 70 years and probably under-recognised and undertreated; 25% of participants had osteoporosis.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=228

Incidence and progression of thyroid dysfunction in elderly

Gopinath B, et al. Five-year incidence and progression of thyroid dysfunction in an older population. Internal Medicine Journal 2010;40(9):642–649
The rate of progression from subclinical to overt hypothyroidism in older people is about 1 in 6 over five years.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=182

Severe hypoglycemia and risk of vascular events and death

Zoungas S, et al. Severe hypoglycemia and risk of vascular events and death. N Engl J Med 2010;363:1410-8
Severe hypoglycaemia is strongly associated with increased risk of vascular events and death (~ 350% ↑ risk).

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=206

Subclinical hypothyroidism and coronary heart disease

Rondondi N, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-1374.
Subclinical hypothyroidism (elevated TSH with normal thyroxine levels) is associated with increased risk of coronary heart disease (CHD) events and mortality.

Permanent link to this article: https://evidencebasedmedicine.com.au/?p=162