Jun 22 2011
Connolly SJ, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361:1139-1151
Dabigatran (Pradaxa) is non-inferior to warfarin for the prevention of strokes or systemic embolism, in non-valvular atrial fibrillation.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1443
May 04 2011
Martinez FD, et al. Use of beclomethasone dipropionate as rescue treatment for mild persistent asthma…. Lancet 2011; 377: 650–57
Inhaled beclomethasone (Qvar) used as rescue therapy with salbutamol is likely better than salbutamol alone, for children with mild persistent asthma who do not take regular inhaled corticosteroids.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1420
Apr 20 2011
Ray KK, et al. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 RCTs… Archives of Internal Medicine, 2010; 170(12): 1024-31 Statins were not associated with a benefit to all-cause mortality in a primary prevention setting.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1341
Mar 16 2011
Chlebowski R, et al. Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA. 2010; 304 (15):1684-1692
Combined oestrogen and progestin HRT is associated with increased risk of invasive breast cancer, node-positivity, and all cause mortality.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1062
Mar 09 2011
Freeman EW, et al. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA. 2001; 305(3): 267-74
Escitalopram is probably associated with a mild improvement in the frequency and severity of hot flushes in peri-menopausal women.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1075
Mar 07 2011
Trelle S, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011; 342:c7086
Non-steroidal anti-inflammatory drugs (NSAIDs) appear to be associated with increased cardiovascular risks.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1173
Mar 04 2011
Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 2010;304(8):859-866
No association was found between the use of aciclovir (Zovirax), or valaciclovir (Valtrex), in early pregnancy and major birth defects.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1046
Mar 02 2011
Makrides M, et al. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA. 2010; 304(15): 1675-1683
DHA supplements in the later half of pregnancy are not associated with improvements in maternal depression or infant neurodevelopment.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=989
Feb 28 2011
Galan P, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a RCT. BMJ 2010; 341:c6273
B-vitamin and low dose omega-3 fatty acid supplements are not associated with better vascular outcomes in people with ischaemic heart disease and stroke.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=993
Feb 18 2011
Kowey PR, et al. Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation. JAMA 2010; 304(21): 2363-72
High dose omega-3 fatty acids were not associated with a benefit in prevention of recurrent symptomatic AF.
Permanent link to this article: https://evidencebasedmedicine.com.au/?p=1264
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