Category: Clinical domain

Nov 06

Baclofen as treatment for alcohol use disorders

Garbutt et al. Alcohol Clin Exp Res 2010 Nov;34(11):1849-57
Baclofen cannot be recommended as a routine treatment for alcohol use disorders. The quality of the evidence is low overall.

Aug 31

Do vitamin D supplements reduce falls in older people living in the community?

Bolland et al. Lancet Diabetes Endocrinol 2014 Jul;2(7):573-80
The beneficial effect of vitamin D on falls in otherwise well community-dwelling people is likely to be small, if it exists at all. Its routine preventive use cannot be justified on the evidence.

Jul 03

Should PPIs be routinely co-prescribed with long-term NSAIDs?

Rostom et al. Cochrane database of systematic reviews 2002(4):CD002296.
Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs. Little data exists on clinical outcomes.

Jun 09

NSAIDs as treatment for uncomplicated urinary tract infections

Gagyor et al. BMJ 2015 Dec 23;351:h6544.
NSAIDs should not be recommended as a first line treatment for uncomplicated UTIs in women. Compared to empirical antibiotics, women experienced a significantly greater burden of UTI symptoms.

Mar 01

Duct tape to treat cutaneous warts

Kwok CS, et al. Cochrane database of systematic reviews 2012 Sep 12(9):CD001781
Duct tape should not be routinely recommended as wart therapy. There is no compelling evidence that duct tape is more effective than placebo.

Dec 05

Milk thistle for chronic hepatitis B

Rambaldi et al. Cochrane database Syst Rev 2007 Oct 17(4):CD003620
Milk thistle products cannot be recommended for chronic hepatitis B. Only limited research evidence of unclear/poor quality exists.

Oct 10

Sterile water injections for acute low back pain

Cui JZ, et al. Braz J Med Biol Res 2016 Mar;49(3)
Sterile water injections are of uncertain value in acute low back pain. It may have a role in patients who consent after being informed to its uncertain value.

Aug 08

Does co-enzyme Q10 reduce statin-related muscle pain?

Banach et al. Mayo Clin Proc 2015 Jan;90(1):24-34.
The effect of CoQ10 on muscle pain in people on statin therapy is uncertain with the evidence limited and inconsistent. CoQ10 cannot be recommended as a matter of routine supplementation to prevent muscle pain in people taking statins.

Jun 14

Metformin as prevention in people taking antipsychotic medication

Zheng et al. J Clin Psychopharmacol 2015 Oct;35(5):499-509.
The effect of metformin on cardiovascular disease in people living without diabetes on long-term antipsychotic medication is unknown.

Feb 19

Aspirin as DVT prophylaxis for high risk long-haul travellers

Cesarone MR, et al. Angiology 2002 Jan-Feb;53(1):1-6.
It is unclear whether aspirin is effective as DVT prophylaxis for high risk long-haul travellers. The lack of evidence should preclude it from being recommended.