Connolly SJ, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361:1139-1151
Dabigatran (Pradaxa) is non-inferior to warfarin for the prevention of strokes or systemic embolism, in non-valvular atrial fibrillation.
Jun
22
Dabigatran versus warfarin for atrial fibrillation
by Michael Tam
Apr
20
Statins in primary prevention and all-cause mortality
Ray KK, et al. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 RCTs… Archives of Internal Medicine, 2010; 170(12): 1024-31 Statins were not associated with a benefit to all-cause mortality in a primary prevention setting.
Mar
02
DHA on maternal depression and neurodevelopment
by May Su
Makrides M, et al. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA. 2010; 304(15): 1675-1683
DHA supplements in the later half of pregnancy are not associated with improvements in maternal depression or infant neurodevelopment.
Feb
28
B-vitamins and omega-3 fatty acids on vascular disease
by Michael Tam
Galan P, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a RCT. BMJ 2010; 341:c6273
B-vitamin and low dose omega-3 fatty acid supplements are not associated with better vascular outcomes in people with ischaemic heart disease and stroke.
Feb
21
Maternal flu vaccination and flu infection in young infants
by Angie Pinto
Eick AA, et al. Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med. 2010;0(2010):archpediatrics.2010.192
Maternal influenza vaccination during pregnancy has a limited effect on infant influenza-like illness.
Feb
16
Daily aspirin on long-term risk of death due to cancer
by Michael Tam
Rothwell PM, et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011; 377(9759): 31-41
Daily aspirin (≥ 75 mg) taken by participants in cardiovascular studies reduced the risk of cancer death.