Journal reference: Derry CJ, Derry S, Moore RA. Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database of Systematic Reviews 2012, Issue 3. Art. No.: CD009281.
Published: 14 March 2012
|Oral caffeine (100 mg) as a single dose may have a modest effect on acute pain (including migraine) when used as an adjuvant to oral analgesia (including paracetamol).
There are significant uncertainties in the evidence-base and this finding should be treated cautiously.
There is an absence of evidence for repeated doses of caffeine.