Journal reference: Tonelli M, Lloyd A, Clement F, Conly J, Husereau D, Hemmelgarn B, Klarenbach S, McAlister FA, Wiebe N, Manns B, Alberta Kidney Disease Network. Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis. CMAJ 2011; 183(16): E1189-E1202
Published: 24 October 2011
|Statins appear to have a (small) cardiovascular benefit, even in individuals at low CVD risk.
The clinical meaningfulness of this benefit needs to be considered in the context of side-effects, opportunity costs, and patient preferences.