Journal reference: Rapaport MH, Nierenberg AA, Howland R, Dording C, Schettler PJ, Mischoulon D. The treatment of minor depression with St. John’s Wort or citalopram: failure to show benefit over placebo. Journal of Psychiatric Research 2011; 45(7): 931-941. DOI: 10.1016/j.jpsychires.2011.05.001
Published: July 2011
|St John’s wort is probably ineffective for minor depression.
Of the little evidence available, there appears to be no benefit over placebo, and evidence of side-effects.